In zones separated by doors with many entrances and exits, it is crucial in terms of energy consumption to protect the conditioned air in the indoor environment from the e®ects of outside air. The increase in door dimensions and opening frequency make this e®ect even more evident. Various methods are used to prevent leakage of outside air into the indoor environment. In this study, we investigated the e®ects of using air curtains on energy consumption during the cooling season in a factory building. The door width and height in this building, which has a high story height, were also large. These 26 doors must remain open all the time because of the production process. With a transient model developed on Transient System Simulation Tool (TRNSYS) coupled with Contaminant Transport Analysis Software (CONTAM), we showed the e®ects of using the air curtains in di®erent climate conditions. As a result, we demonstrated that using air curtains will provide great savings, especially in cities with high cooling requirements.