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| 008 | | 210802s2021 dcua ob 000 0 eng |
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▼z 9780309303361 |
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▼z 0309303362 |
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▼a 9780309304085
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▼a 0309304083
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▼a 3024816
▼b (N$T) |
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▼a (OCoLC)1266896757
▼z (OCoLC)1286906953
▼z (OCoLC)1300799155 |
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▼b eng
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▼a 612.82
▼2 22 |
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▼a 612.82 |
| 110 | 2 |
▼a National Academies of Sciences, Engineering, and Medicine (U.S.).
▼b Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids,
▼e author. |
| 245 | 14 |
▼a The emerging field of human neural organoids, transplants, and chimeras:
▼h [electronic resource]:
▼b science, ethics, and governance /
▼c Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids; Committee on Science, Technology, and Law; Policy and Global Affairs; National Academies of Sciences, Engineering, Medicine. |
| 260 | |
▼a Washington, DC:
▼b National Academies Press,
▼c [2021] |
| 300 | |
▼a 1 online resource (1 PDF file (xvi, 136 pages)) :
▼b illustrations. |
| 336 | |
▼a text
▼b txt
▼2 rdacontent |
| 337 | |
▼a computer
▼b c
▼2 rdamedia |
| 338 | |
▼a online resource
▼b cr
▼2 rdacarrier |
| 490 | 1 |
▼a Consensus study report of the National Academies of Sciences, Engineering, Medicine |
| 504 | |
▼a Includes bibliographical references. |
| 505 | 0 |
▼a Front Matter -- Summary -- 1. Introduction -- 2. The Science of Human Neural Organoids, Transplants, and Chimeras -- 3. Ethical Concerns -- 4. Oversight and Governance -- 5. Public Engagement -- 6. Findings of the Committee -- References -- Appendix A: Biographies of Committee and Staff Members -- Appendix B: Committee Meeting Agendas. |
| 520 | 3 |
▼a Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself. Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research. |
| 536 | |
▼a This activity was supported by contracts from the National Institutes of Health (Sponsor Award Number HHSN263201800029I/75N98019F00861) and The Dana Foundation. This Project has been funded in whole or in part with federal funds from the National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN263201800029I. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. |
| 650 | 0 |
▼a Neurophysiology. |
| 650 | 0 |
▼a Tissues. |
| 650 | 0 |
▼a Transplantation of organs, tissues, etc. |
| 650 | 0 |
▼a Chimerism. |
| 650 | 0 |
▼a Medical ethics. |
| 650 | 0 |
▼a Medical genetics. |
| 650 | 0 |
▼a Brain
▼x Diseases
▼x Alternative treatment. |
| 650 | 0 |
▼a Cell organelles. |
| 650 | 0 |
▼a Intracerebral transplantation. |
| 650 | 12 |
▼a Brain Diseases
▼x therapy |
| 650 | 22 |
▼a Chimerism |
| 650 | 22 |
▼a Organoids |
| 650 | 22 |
▼a Brain Tissue Transplantation |
| 650 | 22 |
▼a Biomedical Research |
| 650 | 22 |
▼a Ethics, Medical |
| 650 | 2 |
▼a Neurophysiology |
| 650 | 2 |
▼a Genetics, Medical |
| 650 | 6 |
▼a Neurophysiologie. |
| 650 | 6 |
▼a Tissus (Histologie) |
| 650 | 6 |
▼a Greffe (Chirurgie) |
| 650 | 6 |
▼a E?thique me?dicale. |
| 650 | 6 |
▼a Ge?ne?tique me?dicale. |
| 650 | 6 |
▼a Cerveau
▼x Maladies
▼x Me?decines paralle?les. |
| 650 | 6 |
▼a Ge?nes chime?res. |
| 650 | 6 |
▼a Organoi?des. |
| 650 | 6 |
▼a Greffes intrace?re?brales. |
| 650 | 7 |
▼a Chimerism.
▼2 fast
▼0 (OCoLC)fst01765046 |
| 650 | 7 |
▼a Medical ethics.
▼2 fast
▼0 (OCoLC)fst01014081 |
| 650 | 7 |
▼a Medical genetics.
▼2 fast
▼0 (OCoLC)fst01014133 |
| 650 | 7 |
▼a Neurophysiology.
▼2 fast
▼0 (OCoLC)fst01036464 |
| 650 | 7 |
▼a Tissues.
▼2 fast
▼0 (OCoLC)fst01151499 |
| 650 | 7 |
▼a Transplantation of organs, tissues, etc.
▼2 fast
▼0 (OCoLC)fst01154919 |
| 651 | 2 |
▼a United States |
| 655 | 4 |
▼a Electronic books. |
| 710 | 2 |
▼a National Academies of Sciences, Engineering, and Medicine (U.S.).
▼b Committee on Science, Technology, and Law.
▼e issuing body. |
| 830 | 0 |
▼a Consensus study report. |
| 856 | 40 |
▼3 EBSCOhost
▼u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3024816 |